Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Numerof, R. (Editor), Dinarello, C. A. (Editor), Asadullah, K. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2006.
• Series: Ernst Schering Research Foundation Workshop, 56
• Subjects: Medicine.; Immunology.; Allergy.; Dermatology.; Cell biology.; Medicine & Public Health.; Allergology.; Cell Biology.

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed the...

Table of Contents:

• Inhibition of IFN-? as a Method of Treatment of Various Autoimmune Diseases, Including Skin Diseases
• Cytokine Targeting in Psoriasis and Psoriatic Arthritis: Beyond TNF?
• Inhibitors of Histone Deacetylases as Anti-inflammatory Drugs
• Dendritic Cell Interactions and Cytokine Production
• Lysosomal Cysteine Proteases and Antigen Presentation
• DCs and Cytokines Cooperate for the Induction of Tregs
• Induction of Immunity and Inflammation by Interleukin-12 Family Members
• The Role of TNF? and IL-17 in the Development of Excess IL-1 Signaling-Induced Inflammatory Diseases in IL-1 Receptor Antagonist-Deficient Mice
• TGF?-Mediated Immunoregulation
• TNF Blockade: An Inflammatory Issue
• IL-1 Family Members in Inflammatory Skin Disease
• Regulatory T Cells in Psoriasis.