Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia

• Κύριοι συγγραφείς: Tonchev, Anton B. (Συγγραφέας), Chaldakov, George N. (Συγγραφέας), Yamashima, Tetsumori (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
• Σειρά: Advances in Anatomy Embryology and Cell Biology, 191
• Θέματα: Medicine.; Neurosciences.; Biomedicine.

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Πίνακας περιεχομένων:

• 1 Introduction.-.1 Studies on cell proliferation in adult primate brain
• 1.2 Methodological considerations in detecting cell proliferation
• 1.3 Cell proliferation in rodent brain after ischemia
• 1.4 Global cerebral ischemia in primates
• 2 Materials and Methods
• 2.1 Animal subjects
• 2.2 Bromodeoxyuridine infusion protocol
• 2.3 Tissue processing
• 2.4 Immunohistochemistry
• 2.5 Detection of DNA damage and degenerating cells
• 2.6 Electron microscopy
• 2.7 Image acquisition and analysis
• 2.8 Statistical analysis
• 3 Results
• 3.1 Hippocampal formation
• 3.1.1 Dentate gyrus
• 3.1.2 Cornu Ammonis
• 3.1.3 Subiculum
• 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi)
• 3.3 Temporal lobe
• 3.3.1 Parahippocampal region
• 3.3.2 Temporal neocortex
• 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa)
• 3.5 Rostral migratory stream and olfactory bulb
• 3.6 Frontal neocortex and striatum
• 4 Discussion
• 4.1 BrdU as a proliferation marker
• 4.2 Effects of ischemia on cell proliferation and differentiation
• 4.3 Sustained progenitor cell existence in germinative zones
• 4.4 Implications of monkey findings for therapies in humans
• 5 Summary
• References
• Subject Index.