GPCRs: From Deorphanization to Lead Structure Identification

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bourne, H. (Editor), Horuk, R. (Editor), Kuhnke, J. (Editor), Michel, H. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
• Series: Ernst Schering Foundation Symposium Proceedings, 2006/2
• Subjects: Medicine.; Medical microbiology.; Pharmacology.; Chemoinformatics.; Medical biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Medical Biochemistry.; Computer Applications in Chemistry.; Medical Microbiology.

Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by lead...

Table of Contents:

• G-Proteins and GPCRs: From the Beginning
• Modeling GPCRs
• QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications
• Privileged Structures in GPCRs
• Designing Compound Libraries Targeting GPCRs
• Orphan Seven Transmembrane Receptor Screening
• The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling
• Deorphanization of G-Protein-Coupled Receptors
• Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target
• Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins
• High Content Screening to Monitor G Protein-Coupled Receptor Internalisation
• High-Throughput Lead Finding and Optimisation for GPCR Targets.