PET Chemistry The Driving Force in Molecular Imaging /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Schubiger, P. A. (Editor), Lehmann, L. (Editor), Friebe, M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
• Series: Ernst Schering Research Foundation Workshop, 64
• Subjects: Chemistry.; Inorganic chemistry.; Organic chemistry.; Bioorganic chemistry.; Nuclear chemistry.; Nuclear medicine.; Chemistry/Food Science, general.; Nuclear Medicine.; Nuclear Chemistry.; Organic Chemistry.; Inorganic Chemistry.; Bioorganic Chemistry.

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?...

Table of Contents:

• Molecular Imaging with PET — Open Questions?
• Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions
• Fluorine-18 Labeling of Small Molecules: The Use of 18F-Labeled Aryl Fluorides Derived from No-Carrier-Added [18F]Fluoride as Labeling Precursors
• Fluorine-18 Labeling of Peptides and Proteins
• [18F]Fluoropyridines: From Conventional Radiotracers to the Labeling of Macromolecules Such as Proteins and Oligonucleotides
• Production of Non-standard PET Radionuclides and the Application of Radiopharmaceuticals Labeled with these Nuclides
• Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide
• 68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy
• Microwaving in F-18 Chemistry: Quirks and Tweaks
• Micro-reactors for PET Tracer Labeling
• Synthesis Modules and Automation in F-18 Labeling
• Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research
• Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development.