T Cell Activation by CD1 and Lipid Antigens

• Corporate Author: SpringerLink (Online service)
• Other Authors: Moody, D. Branch (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.
• Series: Current Topics in Microbiology and Immunology, 314
• Subjects: Medicine.; Immunology.; Biomedicine.

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipid...