Protein-Protein Interactions as New Drug Targets

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Klussmann, Enno (Επιμελητής έκδοσης), Scott, John (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.
• Σειρά: Handbook of Experimental Pharmacology, 186
• Θέματα: Medicine.; Molecular biology.; Pharmacology.; Medical biochemistry.; Cell biology.; Biomedicine.; Pharmacology/Toxicology.; Cell Biology.; Medical Biochemistry.; Molecular Medicine.
• Φυσική περιγραφή: XV, 512 p. online resource.
• ISBN: 9783540728436
• ISSN: 0171-2004 ;

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.