Sparking Signals Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Baier, G. (Editor), Schraven, B. (Editor), Zügel, U. (Editor), von Bonin, A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.
• Series: Ernst Schering Foundation Symposium Proceedings, 2007/3
• Subjects: Medicine.; Immunology.; Pharmacology.; Biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Biochemistry, general.

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance...

Table of Contents:

• Proteomics-Based Strategies in Kinase Drug Discovery
• PKC Isotype Functions in T Lymphocytes
• Migration, Cell–Cell Interaction and Adhesion in the Immune System
• Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts
• Fragment-Based Drug Discovery Using Rational Design
• Systems Biology of T Cell Activation
• Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice
• Sensing, Presenting, and Regulating PAMPS
• The Role of Diacylglycerol Kinases in T Cell Anergy.