Telomeres and Telomerase in Ageing, Disease, and Cancer Molecular Mechanisms of Adult Stem Cell Ageing /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rudolph, K. Lenhard (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.
• Subjects: Medicine.; Cancer research.; Human genetics.; Biochemistry.; Cell biology.; Biomedicine.; Human Genetics.; Biochemistry, general.; Cell Biology.; Cancer Research.

The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly. Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumula...

Table of Contents:

• Telomere Shortening and Ageing
• Cellular versus Organismal Aging
• Telomere-Induced Senescence of Primary Cells
• Telomeres, Senescence, Oxidative Stress, and Heterogeneity
• Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres
• Telomerase Mutations and Premature Ageing in Humans
• Telomerase, Telomeres, and Stem Cell Aging
• Mechanisms of Stem Cell Ageing
• Senescence Signatures of Human Hematopoietic Stem Cells
• Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function
• p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
• Telomerase as a Potential Regulator of Tissue Progenitor Cells
• Telomeres, DNA Damage and Cancer
• Telomere Shortening and Telomerase Activation during Cancer Formation
• Telomere Binding Proteins and Disease
• Therapeutic Targets
• Targeting Telomerase: Therapeutic Options for Cancer Treatment
• Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?.