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03421nam a22005295i 4500 |
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978-3-540-74229-6 |
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DE-He213 |
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20151125151048.0 |
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cr nn 008mamaa |
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100301s2008 gw | s |||| 0|eng d |
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|a 9783540742296
|9 978-3-540-74229-6
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|a 10.1007/978-3-540-74229-6
|2 doi
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|a RS400-431
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|a SCI013020
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|a 615.19
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|a Alzheimer's Disease
|h [electronic resource] /
|c edited by Lit-Fui Lau, Michael A. Brodney.
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|a With contributions by numerous experts
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg,
|c 2008.
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| 300 |
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|a XIII, 179 p.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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|a Topics in Medicinal Chemistry,
|x 1862-2461 ;
|v 2
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| 505 |
0 |
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|a Therapeutic Approaches for the Treatment of Alzheimer's Disease: An Overview -- Cholinesterase Inhibitors -- Beyond Cholesterol: Statin Benefits in Alzheimer's Disease -- PPAR? Agonists for the Treatment of Alzheimer's Disease -- Metal Complexing Agents for the Treatment of Alzheimer's Disease -- GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.
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|a Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors). This volume will first review existing cholinesterase inhibitors prescribed for AD patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. It also provides an interesting read on why and how current medicines for other indications could potentially be used to treat AD.
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| 650 |
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|a Chemistry.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Organic chemistry.
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| 650 |
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|a Medicinal chemistry.
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4 |
|a Chemistry.
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|a Medicinal Chemistry.
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|a Pharmacology/Toxicology.
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| 650 |
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|a Organic Chemistry.
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| 650 |
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|a Molecular Medicine.
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| 700 |
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|a Lau, Lit-Fui.
|e editor.
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| 700 |
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|a Brodney, Michael A.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9783540742289
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| 830 |
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|a Topics in Medicinal Chemistry,
|x 1862-2461 ;
|v 2
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-3-540-74229-6
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-CMS
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| 950 |
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|a Chemistry and Materials Science (Springer-11644)
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