Retrotransposition, Diversity and the Brain

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gage, Fred H. (Editor), Christen, Yves (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.
• Series: Research and Perspectives in Neurosciences,
• Subjects: Medicine.; Human genetics.; Neurosciences.; Neurology.; Medicine & Public Health.; Human Genetics.

Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or "junk" DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives, L1 sequences constitute almost 50% of the mammalian...

Table of Contents:

• Telomeres and Telomerase in Human Health and Disease
• Molecular and Circuit Mechanisms for Hippocampal Learning
• Retrotransposons – Natural and Synthetic
• Ancient Retrotransposons as Possible Remnants of the Primitive RNPWorld
• Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential
• From the “RNAWorld” to Brain Complexity: Generation of Diversity
• Endogenous Retroviruses and Human Neuropsychiatric Disorders
• Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene?
• Microcephalies and DNA Repair.