Antiviral Strategies

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kräusslich, Hans-Georg (Editor), Bartenschlager, Ralf (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Series: Handbook of Experimental Pharmacology, 189
• Subjects: Medicine.; Gene therapy.; Drug resistance.; Pharmacology.; Pharmaceutical technology.; Virology.; Biomedicine.; Pharmacology/Toxicology.; Pharmaceutical Sciences/Technology.; Drug Resistance.; Gene Therapy.

A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combinati...

Table of Contents:

• Antiviral Strategies
• Approaches for the Development of Antiviral Compounds: The Case of Hepatitis C Virus
• Antiviral Agents Acting as DNA or RNA Chain Terminators
• Viral Protease Inhibitors
• Anti-Influenza Drugs: The Development of Sialidase Inhibitors
• Other Inhibitors of Viral Enzymes and Functions
• Inhibitors of Viral Entry
• Interferons and Their Use in Persistent Viral Infections
• Nucleic Acids-Based Therapeutics in the Battle Against Pathogenic Viruses
• Antiviral Gene Therapy
• Antiviral Resistance and Impact on Viral Replication Capacity: Evolution of Viruses Under Antiviral Pressure Occurs in Three Phases
• Antiviral Combination Therapy for Treatment of Chronic Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Infection
• Socio-Economic Impact of Antiviral Intervention.