Elements of Synthesis Planning

• Main Author: Hoffmann, R.W (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Edition: 1.
• Subjects: Chemistry.; Organic chemistry.; Medicinal chemistry.; Biochemistry.; Organic Chemistry.; Medicinal Chemistry.; Biochemistry, general.

Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involv...

Table of Contents:

• Functional Group Oriented Bond-Sets
• Skeleton Oriented Bond-Sets
• Building Block Oriented Synthesis
• The Basis for Planning
• Formation of Cyclic Structures
• Protecting Groups
• Ranking of Synthesis Plans
• Computer-Aided Synthesis Planning
• Stereogenic Centers and Planning of Syntheses
• Enjoying the Art of Synthesis
• Summary and Concluding Remarks
• Solutions to Problems.