Neuroanatomy and Pathology of Sporadic Parkinson's Disease

• Main Authors: Braak, Heiko (Author), Tredici, Kelly Del (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Series: Advances in Anatomy, Embryology and Cell Biology, 201
• Subjects: Medicine.; Neurosciences.; Biomedicine.

The proteinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The a -synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric...

Table of Contents:

• Prologue
• Morphology of Lewy Pathology
• The Evolving Distribution Pattern of Lewy Pathology Associated with sPD Renders Neuropathological Staging Possible
• Stage 1
• Stage 2
• Stage 3
• Stage 4
• Stages 5 and 6
• The Progression of the Cortical Lesions Mimics the Pattern of Myelination in Reverse Order
• The Staging Hypothesis: Assumptions, Challenges, Potential.