Intracellular Traffic and Neurodegenerative Disorders

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: George-Hyslop, Peter H. St (Επιμελητής έκδοσης), Mobley, William C. C. (Επιμελητής έκδοσης), Christen, Yves (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Σειρά: Research and Perspectives in Alzheimer's Disease,
• Θέματα: Medicine.; Neurosciences.; Biomedicine.

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the...

Πίνακας περιεχομένων:

• Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms
• Intramembrane Proteolysis by ?-Secretase and Signal Peptide Peptidases
• Axonal Transport and Neurodegenerative Disease
• Simple Cellular Solutions to Complex Problems
• Tau and Intracellular Transport in Neurons
• Signaling Between Synapse and Nucleus During Synaptic Plasticity
• Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?
• Membrane Trafficking and Targeting in Alzheimer's Disease
• Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport
• The Role of Retromer in Neurodegenerative Disease
• Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease
• The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease
• Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA.