Small Molecules in Oncology

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Martens, Uwe M. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010.
• Σειρά: Recent Results in Cancer Research, 184
• Θέματα: Medicine.; Cancer research.; Hematology.; Oncology.; Medicine & Public Health.; Cancer Research.

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small m...

Πίνακας περιεχομένων:

• Protein kinase inhibitors
• Imatinib Mesylate
• Erlotinib
• Axitinib (AG-013736)
• Lapatinib
• Sorafenib
• Sunitinib
• Dasatinib
• Nilotinib
• Bosutinib
• Epigenetic modifiers
• Decitabine
• 5-Azacytidine/Azacitidine
• Cell cycle inhibitors
• Bortezomib
• Temsirolimus
• Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor
• BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1)
• Other novel agents
• Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy
• GDC-0449 - Targeting the Hedgehog Signaling Pathway.