Molecular Biology of the SARS-Coronavirus

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Lal, Sunil K. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010.
• Θέματα: Life sciences.; Medical microbiology.; Virology.; Infectious diseases.; Cell biology.; Microbiology.; Microbial genetics.; Microbial genomics.; Life Sciences.; Microbial Genetics and Genomics.; Medical Microbiology.; Cell Biology.; Infectious Diseases.

SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spre...

Πίνακας περιεχομένων:

• Viral Entry
• Cellular Entry of the SARS Coronavirus: Implications for Transmission, Pathogenicity and Antiviral Strategies
• The Cell Biology of the SARS Coronavirus Receptor, Angiotensin-Converting Enzyme 2
• Structural Molecular Insights into SARS Coronavirus Cellular Attachment, Entry and Morphogenesis
• Structures Involved in Viral Replication and Gene Expression
• RNA Higher-Order Structures Within the Coronavirus 5? and 3? Untranslated Regions and Their Roles in Viral Replication
• Programmed –1 Ribosomal Frameshifting in SARS Coronavirus
• Viral Proteins
• Expression and Functions of SARS Coronavirus Replicative Proteins
• SARS Coronavirus Replicative Enzymes: Structures and Mechanisms
• Quaternary Structure of the SARS Coronavirus Main Protease
• The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential
• SARS Coronavirus Accessory Gene Expression and Function
• SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis
• Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab
• Viral pathogenesis and host immune response
• SARS Coronavirus Pathogenesis and Therapeutic Treatment Design
• Modulation of Host Cell Death by SARS Coronavirus Proteins
• SARS Coronavirus and Lung Fibrosis
• Host Immune Responses to SARS Coronavirus in Humans
• The Use of Retroviral Pseudotypes for the Measurement of Antibody Responses to SARS Coronavirus
• SARS Coronavirus Spike Protein Expression in HL-CZ Human Promonocytic Cells: Monoclonal Antibody and Cellular Transcriptomic Analyses
• Signaling Pathways of SARS-CoV In Vitro and In Vivo.