Transformative Concepts for Drug Design: Target Wrapping

• Κύριος συγγραφέας: Fernandez, Ariel (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010.
• Θέματα: Engineering.; Cancer research.; Medicinal chemistry.; Biophysics.; Biological physics.; Biomedical engineering.; Biomedical Engineering.; Medicinal Chemistry.; Biophysics and Biological Physics.; Cancer Research.

In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful t...

Πίνακας περιεχομένων:

• Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy
• Wrapping Defects and the Architecture of Soluble Proteins
• Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins
• Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design
• Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation
• Evolution of Protein Wrapping and Implications for the Drug Designer
• Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence
• Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
• Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
• Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact
• Inducing Folding By Crating the Target
• Wrapper Drugs as Therapeutic Editors of Side Effects
• Wrapper Drugs for Personalized Medicine
• Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design.