Phosphoinositide 3-kinase in Health and Disease Volume 1 /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Rommel, Christian (Επιμελητής έκδοσης), Vanhaesebroeck, Bart (Επιμελητής έκδοσης), Vogt, Peter K. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
• Σειρά: Current Topics in Microbiology and Immunology, 346
• Θέματα: Medicine.; Cancer research.; Human physiology.; Molecular biology.; Biomedicine.; Cancer Research.; Human Physiology.; Molecular Medicine.

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in pro...

Πίνακας περιεχομένων:

• PI3K – From the Bench to the Clinic and Back
• PI3K Book Introduction
• PDK1: The major transducer of PI 3-Kinase actions
• Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
• Regulatory subunits of class IA PI3K
• The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions
• Phosphoinositide signalling pathways in metabolic regulation
• Role of RAS in the regulation of PI 3-kinase
• More than just kinases: The scaffolding function of PI3K
• PI3K signalling in neutrophils
• PI 3-kinase p110beta regulation of platelet integrin alphaIIbbeta3
• PI3Ks in lymphocyte signalling and development
• PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
• Taking PI3Kdelta and PI3Kgamma one step ahead – Dual active PI3Kdelta/gamma inhibitors for the treatment of immune-mediated inflammatory diseases
• Oncogenic Mutations of PIK3CA in Human Cancers
• Structural Effects of Oncogenic PI3Kalpha Mutations
• Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer
• Phosphatidylinositol 3-kinase (PI3K): The oncoprotein
• AKT Signaling in Physiology and Disease
• Faithfull modeling of PTEN loss driven diseases in the mouse
• PI3K as a target for therapy in haematological malignancies
• Clinical development of Phosphatidylinositol-3 kinase pathway inhibitors
• New inhibitors of the PI3K-Akt-mTOR pathway: Insights into mTOR signaling from a new generation of Tor kinase domain inhibitors (TORKinibs)
• Small molecule inhibitors of the PI3-kinase family
• Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance
• Subject index.