Drug Transporters

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are mos...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Fromm, Martin F. (Επιμελητής έκδοσης), Kim, Richard B. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011.
Σειρά:Handbook of Experimental Pharmacology, 201
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 1 0 |a Drug Transporters  |h [electronic resource] /  |c edited by Martin F. Fromm, Richard B. Kim. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg,  |c 2011. 
300 |a X, 454 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
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490 1 |a Handbook of Experimental Pharmacology,  |x 0171-2004 ;  |v 201 
505 0 |a From the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport. 
520 |a It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies. 
650 0 |a Medicine. 
650 0 |a Human physiology. 
650 0 |a Drug resistance. 
650 0 |a Pharmacology. 
650 0 |a Pharmaceutical technology. 
650 0 |a Hepatology. 
650 0 |a Nephrology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Pharmacology/Toxicology. 
650 2 4 |a Pharmaceutical Sciences/Technology. 
650 2 4 |a Human Physiology. 
650 2 4 |a Drug Resistance. 
650 2 4 |a Hepatology. 
650 2 4 |a Nephrology. 
700 1 |a Fromm, Martin F.  |e editor. 
700 1 |a Kim, Richard B.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783642145407 
830 0 |a Handbook of Experimental Pharmacology,  |x 0171-2004 ;  |v 201 
856 4 0 |u http://dx.doi.org/10.1007/978-3-642-14541-4  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)