Phosphoinositide 3-kinase in Health and Disease Volume 2 /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Rommel, Christian (Επιμελητής έκδοσης), Vanhaesebroeck, Bart (Επιμελητής έκδοσης), Vogt, Peter K. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
• Σειρά: Current Topics in Microbiology and Immunology, 347
• Θέματα: Medicine.; Cancer research.; Biomedicine.; Cancer Research.
• Φυσική περιγραφή: X, 306 p. 79 illus., 46 illus. in color. online resource.
• ISBN: 9783642148163
• ISSN: 0070-217X ;

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.