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02555nam a22004455i 4500 |
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978-3-642-15473-7 |
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DE-He213 |
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20151204185553.0 |
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cr nn 008mamaa |
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110119s2011 gw | s |||| 0|eng d |
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|a 9783642154737
|9 978-3-642-15473-7
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|a 10.1007/978-3-642-15473-7
|2 doi
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|d GrThAP
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|a QD415-436
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|a SCI013040
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|a 547
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|a Ohta, Yusuke.
|e author.
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|a Copper-Catalyzed Multi-Component Reactions
|h [electronic resource] :
|b Synthesis of Nitrogen-Containing Polycyclic Compounds /
|c by Yusuke Ohta.
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg,
|c 2011.
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| 300 |
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|a XVI, 104 p.
|b online resource.
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|a text
|b txt
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Springer Theses
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|a A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
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|a Chemistry.
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|a Organic chemistry.
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|a Medicinal chemistry.
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|a Chemistry.
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|a Organic Chemistry.
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|a Medicinal Chemistry.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783642154720
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|a Springer Theses
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|u http://dx.doi.org/10.1007/978-3-642-15473-7
|z Full Text via HEAL-Link
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|a ZDB-2-CMS
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|a Chemistry and Materials Science (Springer-11644)
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