The Role of Model Integration in Complex Systems Modelling An Example from Cancer Biology /

Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth lite...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Patel, Manish (Συγγραφέας), Nagl, Sylvia (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010.
Σειρά:Understanding Complex Systems,
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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100 1 |a Patel, Manish.  |e author. 
245 1 4 |a The Role of Model Integration in Complex Systems Modelling  |h [electronic resource] :  |b An Example from Cancer Biology /  |c by Manish Patel, Sylvia Nagl. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg,  |c 2010. 
300 |a X, 168 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
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347 |a text file  |b PDF  |2 rda 
490 1 |a Understanding Complex Systems,  |x 1860-0832 
505 0 |a Nature to Numbers: Complex Systems Modelling of Cancer -- Coping with Complexity: Modelling of Complex Systems -- Complexity and Model Integration: Formalisations -- Novel Strategies for Integrating Models into Systems-Level Simulations -- Experiments in Model Integration -- Discussion. 
520 |a Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value. 
650 0 |a Engineering. 
650 0 |a Cancer research. 
650 0 |a Systems biology. 
650 0 |a Statistical physics. 
650 0 |a Dynamical systems. 
650 0 |a Complexity, Computational. 
650 1 4 |a Engineering. 
650 2 4 |a Complexity. 
650 2 4 |a Statistical Physics, Dynamical Systems and Complexity. 
650 2 4 |a Systems Biology. 
650 2 4 |a Cancer Research. 
700 1 |a Nagl, Sylvia.  |e author. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783642156021 
830 0 |a Understanding Complex Systems,  |x 1860-0832 
856 4 0 |u http://dx.doi.org/10.1007/978-3-642-15603-8  |z Full Text via HEAL-Link 
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950 |a Physics and Astronomy (Springer-11651)