|
|
|
|
| LEADER |
02520nam a22005655i 4500 |
| 001 |
978-3-642-17969-3 |
| 003 |
DE-He213 |
| 005 |
20151103123147.0 |
| 007 |
cr nn 008mamaa |
| 008 |
110621s2011 gw | s |||| 0|eng d |
| 020 |
|
|
|a 9783642179693
|9 978-3-642-17969-3
|
| 024 |
7 |
|
|a 10.1007/978-3-642-17969-3
|2 doi
|
| 040 |
|
|
|d GrThAP
|
| 050 |
|
4 |
|a RM1-950
|
| 072 |
|
7 |
|a MMG
|2 bicssc
|
| 072 |
|
7 |
|a MED071000
|2 bisacsh
|
| 082 |
0 |
4 |
|a 615
|2 23
|
| 245 |
1 |
0 |
|a Phosphodiesterases as Drug Targets
|h [electronic resource] /
|c edited by Sharron H. Francis, Marco Conti, Miles D. Houslay.
|
| 264 |
|
1 |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg,
|c 2011.
|
| 300 |
|
|
|a XVIII, 522 p.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 204
|
| 520 |
|
|
|a Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
|
| 650 |
|
0 |
|a Medicine.
|
| 650 |
|
0 |
|a Pharmacology.
|
| 650 |
|
0 |
|a Medicinal chemistry.
|
| 650 |
|
0 |
|a Proteins.
|
| 650 |
|
0 |
|a Enzymology.
|
| 650 |
|
0 |
|a Posttranslational modification.
|
| 650 |
|
0 |
|a Cell physiology.
|
| 650 |
1 |
4 |
|a Biomedicine.
|
| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
|
| 650 |
2 |
4 |
|a Medicinal Chemistry.
|
| 650 |
2 |
4 |
|a Protein Structure.
|
| 650 |
2 |
4 |
|a Enzymology.
|
| 650 |
2 |
4 |
|a Posttranslational Modification.
|
| 650 |
2 |
4 |
|a Cell Physiology.
|
| 700 |
1 |
|
|a Francis, Sharron H.
|e editor.
|
| 700 |
1 |
|
|a Conti, Marco.
|e editor.
|
| 700 |
1 |
|
|a Houslay, Miles D.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 776 |
0 |
8 |
|i Printed edition:
|z 9783642179686
|
| 830 |
|
0 |
|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 204
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-3-642-17969-3
|z Full Text via HEAL-Link
|
| 912 |
|
|
|a ZDB-2-SBL
|
| 950 |
|
|
|a Biomedical and Life Sciences (Springer-11642)
|
