Phosphodiesterases as Drug Targets

• Corporate Author: SpringerLink (Online service)
• Other Authors: Francis, Sharron H. (Editor), Conti, Marco (Editor), Houslay, Miles D. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011.
• Series: Handbook of Experimental Pharmacology, 204
• Subjects: Medicine.; Pharmacology.; Medicinal chemistry.; Proteins.; Enzymology.; Posttranslational modification.; Cell physiology.; Biomedicine.; Pharmacology/Toxicology.; Medicinal Chemistry.; Protein Structure.; Posttranslational Modification.; Cell Physiology.

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that...