Ion Channels and Their Inhibitors

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Gupta, Satya Prakash (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
• Θέματα: Chemistry.; Pharmacy.; Molecular biology.; Medicinal chemistry.; Proteins.; Medicinal Chemistry.; Molecular Medicine.; Protein Science.

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads fo...

Πίνακας περιεχομένων:

• Structural and Functional Discrimination of Membrane
• Proteins
• Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
• Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers
• Advances in Design and Development of Sodium Channel Blockers
• Potassium Channel Blockers as Anti-arrhythmic Agents.-  hERG Potassium Channels in Drug Discovery and Development
• Prediction of hERG Channel Inhibition Using in silico Techniques
• Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators
• Calcium Ion Channels and Their Blockers
• Therapeutic Potential of N-type Voltage Gated Ca2+ Channel
• Chloride Ion Channels: Structure, Functions, and Blockers.