Ion Channels and Their Inhibitors

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gupta, Satya Prakash (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
• Subjects: Chemistry.; Pharmacy.; Molecular biology.; Medicinal chemistry.; Proteins.; Medicinal Chemistry.; Molecular Medicine.; Protein Science.

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads fo...

Table of Contents:

• Structural and Functional Discrimination of Membrane
• Proteins
• Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
• Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers
• Advances in Design and Development of Sodium Channel Blockers
• Potassium Channel Blockers as Anti-arrhythmic Agents.-  hERG Potassium Channels in Drug Discovery and Development
• Prediction of hERG Channel Inhibition Using in silico Techniques
• Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators
• Calcium Ion Channels and Their Blockers
• Therapeutic Potential of N-type Voltage Gated Ca2+ Channel
• Chloride Ion Channels: Structure, Functions, and Blockers.