Permutation Testing for Isotonic Inference on Association Studies in Genetics

• Main Authors: Salmaso, Luigi (Author), Arboretti, Rosa (Author), Corain, Livio (Author), Mazzaro, Dario (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011.
• Series: SpringerBriefs in Statistics
• Subjects: Pharmacy.; Statistics.; Human genetics.; Biotechnology.; Biology > Technique.; Psychometrics.; Statistics for Life Sciences, Medicine, Health Sciences.; Human Genetics.; Biological Techniques.

The purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but com...

Table of Contents:

• Introduction
• Association Studies in Genetics
• The Nonparametric Permutation Methodology
• Statistical Problems of Allelic Association
• Power and Sample Size Simulations
• Case Study
• Conclusions
• References.