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02697nam a22004575i 4500 |
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978-3-642-20820-1 |
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DE-He213 |
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20151125193252.0 |
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cr nn 008mamaa |
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110804s2011 gw | s |||| 0|eng d |
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|a 9783642208201
|9 978-3-642-20820-1
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|a 10.1007/978-3-642-20820-1
|2 doi
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|d GrThAP
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|a QH324.2-324.25
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|a PSD
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|a 570.285
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|a Prinz, Heino.
|e author.
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|a Numerical Methods for the Life Scientist
|h [electronic resource] :
|b Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB /
|c by Heino Prinz.
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2011.
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|a IX, 149 p. 61 illus., 52 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches. .
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|a Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
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|a Life sciences.
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|a Bioinformatics.
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|a Biomathematics.
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|a Life Sciences.
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|a Bioinformatics.
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|a Computational Biology/Bioinformatics.
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|a Mathematical and Computational Biology.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783642208195
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|u http://dx.doi.org/10.1007/978-3-642-20820-1
|z Full Text via HEAL-Link
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|a ZDB-2-SBL
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|a Biomedical and Life Sciences (Springer-11642)
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