Bispecific Antibodies

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kontermann, Roland E. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
• Subjects: Medicine.; Cancer research.; Antibodies.; Oncology.; Biomedicine.; Cancer Research.

The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A...