Regulatory RNAs Basics, Methods and Applications /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Mallick, Bibekanand (Επιμελητής έκδοσης), Ghosh, Zhumur (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2012.
• Θέματα: Life sciences.; Gene expression.; Molecular biology.; Biochemistry.; Cell biology.; Developmental biology.; Life Sciences.; Biochemistry, general.; Cell Biology.; Gene Expression.; Molecular Medicine.; Developmental Biology.

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in th...

Πίνακας περιεχομένων:

• Renaissance of Regulatory RNAs
• Diversity, overlap and relationships in the small RNA landscape
• Fragments of small nucleolar RNAs as a new source for non-coding RNAs
• Small regulatory RNAs (sRNAs) – key players in prokaryotic metabolism, stress response and virulence
• The canonical RNA interference pathway in animals
• Generation of functional long non-coding RNA through transcription and natural selection
• MicroRNA regulation of neuronal differentiation and plasticity
• Long Non-coding RNA Function and Expression in Cancer
• Expression profiling of ncRNAs employing RNP libraries and custom LNA/DNA microarray analysis
• Targeted methods to improve small RNA profiles generated by deep sequencing
• Biocomputational identification of bacterial small RNAs and their target binding sites
• Identifying functional miRNA targets using over-expression and knockdown methods
• Identification of lncRNAs using computational and experimental approaches
• Experimental analyses of RNA-based regulations in Bacteria
• Microregulators ruling over pluripotent stem cells.-  The role of RNA-interference in targeting the cancer stem cell and clinical trials for cancer
• microRNAs in development, stem cell differentiation and regenerative medicine
• The role of microRNAs in neurodegenerative diseases: Implications for early detection and treatment
• siRNA therapeutic design: tools and challenges
• Artificial MicroRNA and its Applications
• Deep sequencing of microRNAs in cancer: Expression profiling and its applications.