Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

• Corporate Author: SpringerLink (Online service)
• Other Authors: Vogel, H. Gerhard (Editor), Maas, Jochen (Editor), Hock, Franz J. (Editor), Mayer, Dieter (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013.
• Subjects: Medicine.; Pharmacology.; Biomedicine.; Pharmacology/Toxicology.

Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound...