Fragment-Based Drug Discovery and X-Ray Crystallography

• Corporate Author: SpringerLink (Online service)
• Other Authors: Davies, Thomas G. (Editor), Hyvönen, Marko (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2012.
• Series: Topics in Current Chemistry, 317
• Subjects: Chemistry.; Pharmaceutical technology.; Organic chemistry.; Crystallography.; Organic Chemistry.; Pharmaceutical Sciences/Technology.

D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D. F. Wyss Y.-S. Wang H. L. Eaton C. Stricklan...

Table of Contents:

• D. A. Erlanson Introduction to Fragment-Based Drug Discovery
• T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography
• S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening
• D. F. Wyss Y.-S. Wang H. L. Eaton C. Strickland J.s H. Voigt Z. Zhu A. W. Stamford Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors
• M. Hennig A. Ruf Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery
• E. Valkov T. Sharpe M. Marsh Sa. Greive M. Hyvönen Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery
• J.h D. Bauman D. Patel E. Arnold Fragment Screening and HIV Therapeutics
• D. Rognan Fragment-Based Approaches and Computer-Aided Drug Discovery.