Drug Discovery in Africa Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Chibale, Kelly (Επιμελητής έκδοσης), Davies-Coleman, Mike (Επιμελητής έκδοσης), Masimirembwa, Collen (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
• Θέματα: Chemistry.; Pharmacy.; Organic chemistry.; Medicinal chemistry.; Medical biochemistry.; Medicinal Chemistry.; Organic Chemistry.; Medical Biochemistry.

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threa...

Πίνακας περιεχομένων:

• Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases
• The National Cancer Institute and Natural Product Based Drug Discovery in Africa
• Tuberculosis Drug Discovery: Target Identification and Validation
• Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response
• Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug-Discovery Paradigms
• Searching for Drugs that Target Multiple Receptors for Anthelmintics from African Natural Products
• Application of in silico, in vitro and in vivo ADMET/PK Platforms in Drug Discovery
• Marine Bioprospecting in Southern Africa
• Natural Products-Based Drug Discovery against Neglected Diseases with Special Reference to African Natural Resources
• ‘Now I heal with pride’ - The Application of Screens-to-Nature (STN) Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery
• Innovative Approaches to Exploiting Traditional Medicines in Malaria
• Anticancer Drug Repositioning against Tropical Diseases: The Example of Methotrexate in the Treatment of Malaria
• Tackling the Problem of Antimalarial Resistance
• Random and Rational Approaches to HIV Drug Discovery in Africa
• Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors
• Natural Products and Antimalarial Drugs. Will Africa Provide the Next Major Breakthrough?
• Nanomedicine in the Development of Drugs for Poverty Related Diseases.