Purinergic Signalling and the Nervous System

• Main Authors: Burnstock, Geoffrey (Author), Verkhratsky, Alexei (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
• Subjects: Medicine.; Human physiology.; Biomedicine.; Human Physiology.

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act...

Table of Contents:

• Introduction
• Early history of purinergic signaling
• Purinergic cotransmission
• Mechanisms of ATP release and inactivation
• Receptors for purines and pyrimidines
• Evolution of purinergic signaling
• Peripheral nervous system
• Purinergic signalling in the central nervous system
• Sensory Nerves
• Special senses
• Ontogeny of purinergic neurotransmission.