RNA and Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Wu, Jane Y. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013.
• Σειρά: Cancer Treatment and Research, 158
• Θέματα: Medicine.; Cancer research.; Human genetics.; Oncology.; Medical biochemistry.; Medicine & Public Health.; Cancer Research.; Human Genetics.; Medical Biochemistry.

In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book...

Πίνακας περιεχομένων:

• Coupling between transcription and alternative splicing
• Detection of alternatively spliced or processed RNAs in cancer using oligonucleotide microarray
• Cancer-associated perturbations in alternative pre-messenger RNA splicing
• Alternative splicing of tumor suppressors and oncogenes
• MicroRNAs in cancer.-The perinucleolar compartment: RNA metabolism and cancer
• Regulation of ARE-mRNA stability by cellular signaling: implications for human cancer
• Alternative pre-mRNA splicing, cell death and cancer
• Oligonucleotide therapeutics in cancer
• Clinical perspective on chemo-resistance and the role of RNA processing.