Epigenetic Therapy of Cancer Preclinical Models and Treatment Approaches /
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include rea...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2014.
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- The fundamental role of epigenetic regulation for normal and disturbed all growth and differentiation
- Mouse models to study DNA methylation in cancer research
- Epigenetic regulation of normal hematopoietic development
- Epigenetic regulation of globin genes and disturbances in hemoglobinopathies
- DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches
- Epigenetic modifications mediated by the AML1/ETO and MLL leukemia fusion proteins
- Epigenetic abnormalities in lung cancer
- Pharmacodynamic Responses to DNA Methyltransferase Inhibition
- Histone Methyltransferases: Opportunities in Cancer Drug Discovery
- Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
- Clinical Implications of Epigenetic Alterations in Lung Cancer
- Epigenetic disturbances in colorectal cancer
- Epigenetic Therapies in Solid Tumours: from preclinical models to clinical trial results.
