Development of Innovative Drugs via Modeling with MATLAB A Practical Guide /

• Main Authors: Gieschke, Ronald (Author), Serafin, Daniel (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Subjects: Medicine.; Pharmacology.; Pharmaceutical technology.; Computer simulation.; Bioinformatics.; Computational biology.; Biomedicine.; Pharmacology/Toxicology.; Pharmaceutical Sciences/Technology.; Simulation and Modeling.; Computer Appl. in Life Sciences.

The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Wr...

Table of Contents:

• Background of pharmacologic modeling
• First example of a computational model
• Differential equations in MATLAB
• Pharmacologic modeling
• Drug-disease modeling
• Population analyses
• Clinical trial simulation
• Graphics-based modeling
• Outlook
• Appendix A: Hints to MATLAB programs
• Appendix B: Solution to exercises.