Thymic Development and Selection of T Lymphocytes

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Boehm, Thomas (Επιμελητής έκδοσης), Takahama, Yousuke (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Σειρά: Current Topics in Microbiology and Immunology, 373
• Θέματα: Medicine.; Cytogenetics.; Human physiology.; Immunology.; Biomedicine.; Human Physiology.
• Φυσική περιγραφή: VII, 132 p. 11 illus., 9 illus. in color. online resource.
• ISBN: 9783642402524
• ISSN: 0070-217X ;

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.