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02804nam a22004935i 4500 |
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978-3-642-40252-4 |
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DE-He213 |
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20151030111526.0 |
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cr nn 008mamaa |
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|a 9783642402524
|9 978-3-642-40252-4
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|a 10.1007/978-3-642-40252-4
|2 doi
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|a 616.079
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|a Thymic Development and Selection of T Lymphocytes
|h [electronic resource] /
|c edited by Thomas Boehm, Yousuke Takahama.
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2014.
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|a VII, 132 p. 11 illus., 9 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
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|a text file
|b PDF
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 373
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|a Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
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|a The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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|a Medicine.
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|a Cytogenetics.
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|a Human physiology.
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| 650 |
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|a Immunology.
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|a Biomedicine.
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| 650 |
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|a Immunology.
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| 650 |
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4 |
|a Human Physiology.
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| 650 |
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4 |
|a Cytogenetics.
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| 700 |
1 |
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|a Boehm, Thomas.
|e editor.
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| 700 |
1 |
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|a Takahama, Yousuke.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783642402517
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| 830 |
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 373
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-3-642-40252-4
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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