Thymic Development and Selection of T Lymphocytes

• Corporate Author: SpringerLink (Online service)
• Other Authors: Boehm, Thomas (Editor), Takahama, Yousuke (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Series: Current Topics in Microbiology and Immunology, 373
• Subjects: Medicine.; Cytogenetics.; Human physiology.; Immunology.; Biomedicine.; Human Physiology.

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in th...

Table of Contents:

• Development and Function of Cortical Thymic Epithelial Cells
• Mechanisms of Thymus Medulla Development And Function
• Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction
• Trafficking to the Thymus
• The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.