Molecular Mechanisms in Legionella Pathogenesis

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Hilbi, Hubert (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Σειρά: Current Topics in Microbiology and Immunology, 376
• Θέματα: Medicine.; Immunology.; Medical microbiology.; Molecular biology.; Infectious diseases.; Bacteriology.; Biomedicine.; Medical Microbiology.; Infectious Diseases.; Molecular Medicine.

Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative ph...

Πίνακας περιεχομένων:

• From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts
• The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors
• Facets of small RNA-mediated regulation in Legionella pneumophila
• Type II secretion and Legionella virulence
• Effector translocation by the Legionella Icm/Dot type IV secretion system
• Modulation of small GTPases by Legionella
• Host lipidation: A mechanism for spatial regulation of Legionella effectors
• Phosphoinositides and the Legionella pathogen vacuole
• Legionella phospholipases implicated in virulence
• Cytotoxic glucosyltransferases of Legionella pneumophila
• Modulation of the ubiquitination machinery by Legionella
• Host signal transduction and protein kinases implicated in Legionella infection
• Mouse models of Legionnaires´ disease.