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03251nam a22005415i 4500 |
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978-3-642-41199-1 |
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DE-He213 |
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20151030111412.0 |
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cr nn 008mamaa |
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131128s2014 gw | s |||| 0|eng d |
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|a 9783642411991
|9 978-3-642-41199-1
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|a 10.1007/978-3-642-41199-1
|2 doi
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|a RM1-950
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|a MED071000
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|a 615
|2 23
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|a Arrestins - Pharmacology and Therapeutic Potential
|h [electronic resource] /
|c edited by Vsevolod V. Gurevich.
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| 264 |
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1 |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a VIII, 447 p. 53 illus., 42 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 219
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| 505 |
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|a Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
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| 520 |
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|a This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
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| 650 |
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|a Medicine.
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| 650 |
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|a Gene therapy.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Proteins.
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| 650 |
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|a Cell physiology.
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| 650 |
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4 |
|a Biomedicine.
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| 650 |
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|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Biochemistry, general.
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| 650 |
2 |
4 |
|a Protein Structure.
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| 650 |
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4 |
|a Gene Therapy.
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| 650 |
2 |
4 |
|a Cell Physiology.
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| 650 |
2 |
4 |
|a Receptors.
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| 700 |
1 |
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|a Gurevich, Vsevolod V.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783642411984
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| 830 |
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 219
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-3-642-41199-1
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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