Arrestins - Pharmacology and Therapeutic Potential

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Gurevich, Vsevolod V. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Σειρά: Handbook of Experimental Pharmacology, 219
• Θέματα: Medicine.; Gene therapy.; Pharmacology.; Biochemistry.; Proteins.; Cell physiology.; Biomedicine.; Pharmacology/Toxicology.; Biochemistry, general.; Protein Structure.; Gene Therapy.; Cell Physiology.; Receptors.

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arres...

Πίνακας περιεχομένων:

• Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors
• Arrestin-biased GPCR Agonists
• Arrestin-1 Expression Levels, Rod Function and Health
• Protective Functions of Arrestin-1 in Photoreceptors
• Arrestin-4 and Cone Function
• Enhanced Phosphorylation-independent Arrestins and Gene Therapy
• Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking
• Arrestins in Ubiquitination and Deubiquitination
• Arrestin Self-association
• Arrestin-dependent Activation of ERK and Src
• Arrestin-dependent Activation of JNK Family Kinases
• Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization
• Arrestins in Cell Migration
• Arrestins in Host-pathogen Interactions
• Arrestin Regulation of Small GTPases
• GPCRs and Arrestins in Airways: Implications for Asthma
• Arrestins as Regulatory Signaling Hubs in Cancer Pathways
• Arrestins in Pain and Anesthesia.