Voltage Gated Sodium Channels

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ruben, Peter C. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Σειρά: Handbook of Experimental Pharmacology, 221
• Θέματα: Medicine.; Neurosciences.; Pharmacology.; Cardiology.; Proteins.; Cell membranes.; Biomedicine.; Pharmacology/Toxicology.; Membrane Biology.; Protein Structure.

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium chann...

Πίνακας περιεχομένων:

• Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels
• Slow inactivation of Na+ channels
• Regulation/modulation of sensory neuron sodium channels
• Ubiquitylation of voltage-gated sodium channels
• Probing gating mechanisms of sodium channel using pore blockers
• Animal toxins influence voltage-gated sodium channel function
• Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels
• Pharmacological insights and quirks of bacterial sodium channels
• The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels
• The role of late INa in development of cardiac arrhythmias
• Proton modulation of cardiac INa: A potential arrhythmogenic trigger
• Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents. .