Chemical Biology of Nucleic Acids Fundamentals and Clinical Applications /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Erdmann, Volker A. (Επιμελητής έκδοσης), Markiewicz, Wojciech T. (Επιμελητής έκδοσης), Barciszewski, Jan (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Σειρά: RNA Technologies
• Θέματα: Life sciences.; Human genetics.; Molecular biology.; Nucleic acids.; Life Sciences.; Nucleic Acid Chemistry.; Molecular Medicine.; Human Genetics.

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their anal...

Πίνακας περιεχομένων:

• RNA as Major Components in Chemical Evolvable Systems
• How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems
• Isomerization of RNA Phosphodiester Linkages
• Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids
• Oxidative Damage on RNA Nucleobases
• Use of FRET to Study Dynamics of DNA Replication
• Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds
• Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies
• Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids
• Sequence Selective Recognition of Double-Stranded RNA
• Determining Transient Nucleic Acid Structures by NMR
• Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties
• Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms
• Progress in Chemically Modified Nucleic Acid Aptamers
• Aptamers as Molecular Smugglers
• Biochemical Aspects of Subcellular RNA Transport and Localization
• Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
• Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology
• Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
• Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression
• Site Directed Spin Labelling of RNA for Distance Measurements by EPR
• Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells
• Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
• DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics
• Peptides Targeting G-Quadruplex Structures
• Synthesis of Site-Specifically Modified Long-Mer RNAs
• Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs
• mRNA and snRNA Cap Analogs: Synthesis and Applications
• Innovative Chemistry for Synthesis of Regular RNA, 5’-Triphosphate RNA or 5’-Capped RNA.