Small Molecules in Oncology

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targe...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Martens, Uwe M. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
Έκδοση:2nd ed. 2014.
Σειρά:Recent Results in Cancer Research, 201
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 1 0 |a Small Molecules in Oncology  |h [electronic resource] /  |c edited by Uwe M. Martens. 
250 |a 2nd ed. 2014. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2014. 
300 |a XVI, 417 p. 46 illus., 26 illus. in color.  |b online resource. 
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490 1 |a Recent Results in Cancer Research,  |x 0080-0015 ;  |v 201 
505 0 |a Imatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Decitabine -- Azacytidine/Azacitidine -- Bortezomib -- Temsirolimus -- Danusertib -- Vismodegib -- Everolimus -- Vemurafenib -- Vandetanib -- Trametinib -- Dabrafenib -- Ponatinib -- Regorafenib -- Cabozantinib -- Revlimid -- Ibrutinib -- Qizartinib -- Ruxolitinib -- Carfilzomib -- Afitinib. 
520 |a Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. 
650 0 |a Medicine. 
650 0 |a Cancer research. 
650 0 |a Hematology. 
650 0 |a Oncology. 
650 1 4 |a Medicine & Public Health. 
650 2 4 |a Oncology. 
650 2 4 |a Hematology. 
650 2 4 |a Cancer Research. 
700 1 |a Martens, Uwe M.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783642544897 
830 0 |a Recent Results in Cancer Research,  |x 0080-0015 ;  |v 201 
856 4 0 |u http://dx.doi.org/10.1007/978-3-642-54490-3  |z Full Text via HEAL-Link 
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