Optimized Response-Adaptive Clinical Trials Sequential Treatment Allocation Based on Markov Decision Problems /

• Main Author: Ondra, Thomas (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Wiesbaden : Springer Fachmedien Wiesbaden : Imprint: Springer Spektrum, 2015.
• Series: BestMasters
• Subjects: Mathematics.; Mathematical analysis.; Analysis (Mathematics).; Computer mathematics.; Probabilities.; Computational Mathematics and Numerical Analysis.; Probability Theory and Stochastic Processes.; Analysis.

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial desi...

Table of Contents:

• Introduction to Markov Decision Problems and Examples
• Finite and Infinite Horizon Markov Decision Problems
• Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
• Designing Response Adaptive Clinical Trials with Markov Decision Problems.