Modelling Proteasome Dynamics in a Bayesian Framework

• Main Author: Stübler, Sabine (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Wiesbaden : Springer Fachmedien Wiesbaden : Imprint: Springer Spektrum, 2017.
• Series: BestMasters
• Subjects: Medicine.; Immunology.; Bioinformatics.; Cell biology.; Biomedicine.; Cell Biology.

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experi...

Table of Contents:

• Structure and Function of the Proteasome
• Approaches to Model Proteasome Dynamics
• Comparison of the Dynamics of Proteasome Subtypes
• Inhibitor Influence on the Catalytic Subunits
• Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model .  .