Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Nguyen, Hoa Huu Phuc (Editor), Cenci, M. Angela (Editor)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2015.
• Series: Current Topics in Behavioral Neurosciences, 22
• Subjects: Medicine.; Human genetics.; Neurosciences.; Cell biology.; Neurobiology.; Biomedicine.; Human Genetics.; Cell Biology.

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to c...

Table of Contents:

• Clinical Aspects of Huntington’s Disease
• The Neuropathology of Huntington’s Disease
• Neurobiology of Huntington’s Disease
• Mouse Models of Huntington’s Disease
• Transgenic Rat Models of Huntington’s Disease
• Large Animal Models of Huntington’s Disease
• Therapeutic Strategies for Huntington’s Disease
• Clinical and Pathological Features of Parkinson’s Disease
• Symptomatic Models of Parkinson’s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates
• Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?
• Viral Vector-Based Models of Parkinson’s Disease
• Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits
• Modeling LRRK2 Pathobiology in Parkinson’s Disease: From Yeast to Rodents
• Models of Multiple System Atrophy.