Predictive Methods in Percutaneous Absorption

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an intr...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Moss, Gary P. (Συγγραφέας), Gullick, Darren R. (Συγγραφέας), Wilkinson, Simon C. (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2015.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 03660nam a22005055i 4500
001 978-3-662-47371-9
003 DE-He213
005 20151204191117.0
007 cr nn 008mamaa
008 150701s2015 gw | s |||| 0|eng d
020 |a 9783662473719  |9 978-3-662-47371-9 
024 7 |a 10.1007/978-3-662-47371-9  |2 doi 
040 |d GrThAP 
050 4 |a RM1-950 
072 7 |a MMG  |2 bicssc 
072 7 |a MED071000  |2 bisacsh 
082 0 4 |a 615  |2 23 
100 1 |a Moss, Gary P.  |e author. 
245 1 0 |a Predictive Methods in Percutaneous Absorption  |h [electronic resource] /  |c by Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2015. 
300 |a XV, 199 p. 16 illus., 8 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Skin Structure and Physiology -- Methods for the Measurement of Percutaneous Absorption -- Mathematical Treatments and Early Models of Skin Permeability -- “Building error upon error”: The New Breadth of Research in the Field -- Algorithms for Estimating Permeability Across Artificial Membranes -- Other Approaches to Modelling Percutaneous Absorption -- “Squiggly lines and random dots – you can fit anything with a non-linear model” -- Finite-dose models of transient exposures and volatile formulation components -- “The Devil Is in the Detail …” -- Conclusions and Recommendations for Model Development and Use. 
520 |a This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics. 
650 0 |a Medicine. 
650 0 |a Human physiology. 
650 0 |a Pharmacology. 
650 0 |a Dermatology. 
650 0 |a Biomathematics. 
650 1 4 |a Biomedicine. 
650 2 4 |a Pharmacology/Toxicology. 
650 2 4 |a Human Physiology. 
650 2 4 |a Dermatology. 
650 2 4 |a Physiological, Cellular and Medical Topics. 
700 1 |a Gullick, Darren R.  |e author. 
700 1 |a Wilkinson, Simon C.  |e author. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783662473702 
856 4 0 |u http://dx.doi.org/10.1007/978-3-662-47371-9  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)